Structure of PDB 3zbv Chain A Binding Site BS03

Receptor Information
>3zbv Chain A (length=118) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSRYTKFLTQHYDAKPKGRDDRYCESMMVKRKLTSFCKDVNTFIHDTKNN
IKAICGKKGSPYGRNLRISKSHFQVTTCTHKGRSPRPPCRYRASKGFRYI
IIGCENGWPVHFDESFIS
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain3zbv Chain A Residue 1123 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3zbv Crystal Structures of Murine Angiogenin-2 and -3 - Probing 'Structure - Function' Relationships Amongst Angiogenin Homologues.
Resolution1.64 Å
Binding residue
(original residue number in PDB)		G84 R85 S86 R92
Binding residue
(residue number reindexed from 1)		G82 R83 S84 R90
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) H13 K40 H113 F114 D115
Catalytic site (residue number reindexed from 1) H11 K38 H111 F112 D113
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004540 RNA nuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0003300 cardiac muscle hypertrophy
GO:0010467 gene expression
GO:0038166 angiotensin-activated signaling pathway
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070293 renal absorption
GO:0070528 protein kinase C signaling
GO:0071333 cellular response to glucose stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zbv, PDBe:3zbv, PDBj:3zbv
PDBsum3zbv
PubMed23170778
UniProtQ64438|ANG2_MOUSE Angiogenin-2 (Gene Name=Ang2)

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