Structure of PDB 3ufj Chain A Binding Site BS03

Receptor Information
>3ufj Chain A (length=185) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLS
EVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKL
QKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVM
PSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIER
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3ufj Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA.
Resolution2.967 Å
Binding residue
(original residue number in PDB)		P155 G156 R275 A277 P280
Binding residue
(residue number reindexed from 1)		P36 G37 R156 A158 P161
Enzymatic activity
Catalytic site (original residue number in PDB) N140 H151
Catalytic site (residue number reindexed from 1) N21 H32
Enzyme Commision number 3.2.2.29: thymine-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0000700 mismatch base pair DNA N-glycosylase activity
Biological Process
GO:0006285 base-excision repair, AP site formation

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Molecular Function
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Biological Process
External links
PDB RCSB:3ufj, PDBe:3ufj, PDBj:3ufj
PDBsum3ufj
PubMed22573813
UniProtQ13569|TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (Gene Name=TDG)

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