Structure of PDB 3tin Chain A Binding Site BS03

Receptor Information
>3tin Chain A (length=312) Species: 8364 (Xenopus tropicalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSFTYTFVVRDENSTVYAEVAKILLASGQWKRLKRDNPKFNLMLGERNRL
PFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELTETCTWFPES
YVIYPEREEFRSSFNKKKENEEGNVWIAKSSSGGILISSDATELLDFIDN
QGQVHVIQKYLESPLLLEPGHRKFDIRSWVLVDNQYNIYLYREGVLRTSS
EGNEMFFEEFNQYLVTSLNINLENSILCQIKEIIRVCLSCLEPAISTKYL
PYHSFQLFGFDFMVDKNLKVWLIEVNGAPACAQKLYAELCKGIVDLAISS
VFPLNENVFIKL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3tin Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3tin Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y65 R66 Y309 S311
Binding residue
(residue number reindexed from 1)		Y68 R69 Y252 S254
Annotation score1
Enzymatic activity
Enzyme Commision number 6.3.2.25: tubulin--tyrosine ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0036211 protein modification process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3tin, PDBe:3tin, PDBj:3tin
PDBsum3tin
PubMed22020298
UniProtF6Z895

[Back to BioLiP]