Structure of PDB 3t92 Chain A Binding Site BS03

Receptor Information
>3t92 Chain A (length=113) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSRRLSIQRAIQSLVHAAQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGG
CPICKQLIALAAYHAKHCQENKCPVPFCLNIKQKLRQQQLEASIDLSAYI
ESGEEQLLSDLFA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3t92 Chain A Residue 124 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3t92 Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		H70 C74 C79 C84
Binding residue
(residue number reindexed from 1)		H64 C68 C73 C78
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3t92, PDBe:3t92, PDBj:3t92
PDBsum3t92
PubMed25004968
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300);
Q15744

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