Structure of PDB 3qy8 Chain A Binding Site BS03

Receptor Information

>3qy8 Chain A (length=243) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRRKGMFET
PEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLN
DSRYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRV
RELIDMGCYTQVNSSHVLKPKLFGERYKFMKKRAQYFLEQDLVHVIASDM
HNLDGRPPHMAEAYDLVTQKYGEAKAQELFIDNPRKIVMDQLI

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

3qy8 Chain A Residue 254 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	3qy8 Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	D14 H42 H201
Binding residue (residue number reindexed from 1)	D14 H42 H201
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

	Molecular Function
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0030145	manganese ion binding

	Biological Process
GO:0000271	polysaccharide biosynthetic process
GO:0045227	capsule polysaccharide biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3qy8, PDBe:3qy8, PDBj:3qy8
PDBsum	3qy8
PubMed	21605684
UniProt	Q9AHD4\|CPSB_STRPN Tyrosine-protein phosphatase CpsB (Gene Name=cpsB)

[Back to BioLiP]