Structure of PDB 3ova Chain A Binding Site BS03

Receptor Information

>3ova Chain A (length=430) Species: 2234 (Archaeoglobus fulgidus)

VEEILEKALELVIPDEEEVRKGREAEEELRRRLDELGVEYVFVGSYARNT
WLKGSLEIDVFLLFPEEFSKEELRERGLEIGKAVLDSYEIRYAEHPYVHG
VVKGVEVDVVPCYKLKEPKNIKSAVDRTPFHHKWLEGRIKGKENEVRLLK
GFLKANGIYGAEYKVRGFSGYLCELLIVFYGSFLETVKNARRWTRRTVID
VAKGEVRKGEEFFVVDPVDEKRNVAANLSLDNLARFVHLCREFMEAPSLG
FFKPIEPERLRKIVEERGTAVFAVKFRKPDIVDDNLYPQLERASRKIFEF
LERENFMPLRSAFKASEEFCYLLFECQIKEISRVFRRMGPQFEDERNVKK
FLSRNRAFRPFIENGRWWAFEMRKFTTPEEGVRSYASTHWHTLGKNVGES
IREYFEIISGEKLFKEPVTAELCEMMGVKD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3ova Chain A Residue 601

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3ova How the CCA-Adding Enzyme Selects Adenine over Cytosine at Position 76 of tRNA.
• Resolution: 1.98 Å
• Binding residue (original residue number in PDB): E59 D61
• Binding residue (residue number reindexed from 1): E57 D59
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.72: CCA tRNA nucleotidyltransferase.

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0000287 magnesium ion binding
• GO:0003723 RNA binding
• GO:0004810 CCA tRNA nucleotidyltransferase activity
• GO:0005524 ATP binding
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001680 tRNA 3'-terminal CCA addition
• GO:0008033 tRNA processing
• GO:0031123 RNA 3'-end processing
• GO:0042245 RNA repair

External links

• PDB: RCSB:3ova, PDBe:3ova, PDBj:3ova
• PDBsum: 3ova
• PubMed: 21071662
• UniProt: A0A101DCH0