Structure of PDB 3otb Chain A Binding Site BS03

Receptor Information
>3otb Chain A (length=237) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKFEYVRDFEADDTCLAHCWVVVRLDGRNFHRFAEKHNFAKPNDSRALQL
MTKCAQTVMEELEDIVIAYGQSDEYSFVFKRKTNWFKRRASKFMTHVASQ
FASSYVFYWRDYFEDQPLLYPPGFDGRVVVYPSNQTLKDYLSWRQADCHI
NNLYNTVFWALIQQSGLTPVQAQGRLQGTLAADKNEILFSEFNINYNNEL
PMYRKGTVLIWQTKPVPLHCDIIGDAFWKEHPEILDE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3otb Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3otb tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		D29 D76
Binding residue
(residue number reindexed from 1)		D26 D73
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.79: tRNA(His) guanylyltransferase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008193 tRNA guanylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006400 tRNA modification
GO:0006979 response to oxidative stress
GO:0008033 tRNA processing
GO:0008053 mitochondrial fusion
GO:0051289 protein homotetramerization
GO:0099116 tRNA 5'-end processing
GO:1990046 stress-induced mitochondrial fusion
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:1990234 transferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3otb, PDBe:3otb, PDBj:3otb
PDBsum3otb
PubMed21059936
UniProtQ9NWX6|THG1_HUMAN Probable tRNA(His) guanylyltransferase (Gene Name=THG1L)

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