Structure of PDB 3os2 Chain A Binding Site BS03

Receptor Information
>3os2 Chain A (length=365) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIVL
QAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKAS
GPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPTK
APSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEFS
TPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYSP
VLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTPP
ASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHLG
NNRTVSIDNLKPTSH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3os2 The mechanism of retroviral integration from X-ray structures of its key intermediates
Resolution3.32 Å
Binding residue
(original residue number in PDB)		D128 D185 Q186 G187 Y212 E221 R329 R362
Binding residue
(residue number reindexed from 1)		D119 D176 Q177 G178 Y203 E212 R320 R353
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3os2, PDBe:3os2, PDBj:3os2
PDBsum3os2
PubMed21068843
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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