Structure of PDB 3mdc Chain A Binding Site BS03

Receptor Information
>3mdc Chain A (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIP
GIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWY
QQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAA
QAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQ
EGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACAL
LYFTGSAHFNRSMRALAKTKGMSLSEHALSTAGPGRVLPTPTEKDVFRLL
GLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB3mdc Interaction between DNA Polymerase lambda and anticancer nucleoside analogs.
Resolution1.999 Å
Binding residue
(original residue number in PDB)		W274 R275 G278 Y279 G304 G306 R308 M309
Binding residue
(residue number reindexed from 1)		W21 R22 G25 Y26 G51 G53 R55 M56
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D174 D176 D237
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3mdc, PDBe:3mdc, PDBj:3mdc
PDBsum3mdc
PubMed20348107
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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