Structure of PDB 3lsm Chain A Binding Site BS03

Receptor Information

>3lsm Chain A (length=574) Species: 230624 (Trametes ochracea)

IKYDVVIVGSGPIGCTYARELVGAGYKVAMFDIGEIDSGLKIGAHKKNTV
EYQKNIDKFVNVIQGQLMSVSVPVNTLVVDTLSPTSWQASTFFVRNGSNP
EQDPLRNLSGQAVTRVVGGMSTAWTCATPRFDREQRPLLVKDDADADDAE
WDRLYTKAESYFQTGTDQFKESIRHNLVLNKLTEEYKGQRDFQQIPLAAT
RRSPTFVEWSSANTVFDLQNRPNTDAPEERFNLFPAVACERVVRNALNSE
IESLHIHDLISGDRFEIKADVYVLTAGAVHNTQLLVNSGFGQLGRPNPAN
PPELLPSLGSYITEQSLVFCQTVMSTELIDSVKSDMTIRGTPGELTYSVT
YTPGASTNKHPDWWNEKVKNHMMQHQEDPLPIPFEDPEPQVTTLFQPSHP
WHTQIHRDAFSYGAVQQSIDSRLIVDWRFFGRTEPKEENKLWFSDKITDA
YNMPQPTFDFRFPAGRTSKEAEDMMTDMCVMSAKIGGFLPGSLPQFMEPG
LVLHLGGTHRMGFDEKEDNCCVNTDSRVFGFKNLFLGGCGNIPTAYGANP
TLTAMSLAIKSCEYIKQNFTPSPF

Ligand information

• Ligand ID: SO3
• InChI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2
• InChIKey: LSNNMFCWUKXFEE-UHFFFAOYSA-L
• SMILES:
  CACTVS 3.341: [O-][S]([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]S(=O)[O-]
  ACDLabs 10.04: [O-]S([O-])=O
• Formula: O3 S
• Name: SULFITE ION
• PDB chain: 3lsm Chain A Residue 911

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3lsm H-bonding and positive charge at the N5/O4 locus are critical for covalent flavin attachment in trametes pyranose 2-oxidase.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): S293 K576
• Binding residue (residue number reindexed from 1): S249 K532
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.1.3.10: pyranose oxidase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0050233 pyranose oxidase activity
• GO:0050660 flavin adenine dinucleotide binding

Cellular Component

• GO:0042597 periplasmic space

External links

• PDB: RCSB:3lsm, PDBe:3lsm, PDBj:3lsm
• PDBsum: 3lsm
• PubMed: 20708626
• UniProt: Q7ZA32