Structure of PDB 3lqj Chain A Binding Site BS03

Receptor Information

>3lqj Chain A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLP
ESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYR
QQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANS
MVKSFFIRQMERVFPWFSVKKSRFWEP

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

3lqj Chain A Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	3lqj Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	C1588 C1591 C1621 C1624
Binding residue (residue number reindexed from 1)	C24 C27 C57 C60
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.

External links

PDB	RCSB:3lqj, PDBe:3lqj, PDBj:3lqj
PDBsum	3lqj
PubMed	20541251
UniProt	Q03164\|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

[Back to BioLiP]