Structure of PDB 3l2p Chain A Binding Site BS03

Receptor Information
>3l2p Chain A (length=535) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMRHKDCLLREFRKLCAMVADNPSYNTKTQIIQDFLRKGGDVYLTVKLLL
PGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQS
KSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKC
IIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNAQEV
ELSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKN
GDHFSYFSRSLKPVLPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTG
KPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHD
NMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPG
KRHWLKVKKDYLNMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQK
WCTVTKCAGGHDDATLARLQNELDMVKISKAAVWEITGAEFSKSEAHTAD
GISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSK
Ligand information
Receptor-Ligand Complex Structure
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PDB3l2p Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		T301 K302 E303 N336 G338 H341 Y351 K411 G491 V492 H493 K494 K583 H585 G613 Q614 S616 S622 I623 T640 K641 S703 S705 S714 I715 F717
Binding residue
(residue number reindexed from 1)		T127 K128 E129 N162 G164 H167 Y177 K229 G309 V310 H311 K312 K401 H403 G428 Q429 S431 S437 I438 T455 K456 S492 S494 S503 I504 F506
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3l2p, PDBe:3l2p, PDBj:3l2p
PDBsum3l2p
PubMed20518483
UniProtP49916|DNLI3_HUMAN DNA ligase 3 (Gene Name=LIG3)

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