Structure of PDB 3hx0 Chain A Binding Site BS03

Receptor Information
>3hx0 Chain A (length=330) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQKATNHNLHITEKLEVLAKAYSVQGDKWRAAGYAKAINALKSFHKPVTS
YQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAG
TKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEI
EQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFS
RLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVP
YSEFACALLYFTGSAAFNASMRALAKTKGMSLSEHALSTAVVRNTHGAKV
GPGRVLPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB3hx0 Scrunching During DNA Repair Synthesis
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Y267 W274 R275 G278 Y279 G304 G306 R308 M309 K312
Binding residue
(residue number reindexed from 1)		Y22 W29 R30 G33 Y34 G59 G61 R63 M64 K67
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D182 D184 D245
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3hx0, PDBe:3hx0, PDBj:3hx0
PDBsum3hx0
PubMed
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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