Structure of PDB 3hm9 Chain A Binding Site BS03

Receptor Information
>3hm9 Chain A (length=654) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELSLLDYHASKGRLQGREGGRVAWVADPIPHLTGLLVPV
LTLLSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRR
AVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGAS
LRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALL
LREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAV
GFDAGGRESFRFGGAACAVGGDGHLLWTLPEAQAGERIPQEVVWDLLEET
LWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKS
GGGRVYPVQGRLADGLYVPLEDKTFLLLTVGTPRPLKLVHEAGDTPLEAL
AHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREK
LFFV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3hm9 Chain A Residue 687 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3hm9 Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		D478 D546
Binding residue
(residue number reindexed from 1)		D453 D520
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3hm9, PDBe:3hm9, PDBj:3hm9
PDBsum3hm9
PubMed19812667
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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