Structure of PDB 3hct Chain A Binding Site BS03

Receptor Information
>3hct Chain A (length=104) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGH
KCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQA
HCEF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3hct Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3hct E2 interaction and dimerization in the crystal structure of TRAF6.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		C134 C139 H151
Binding residue
(residue number reindexed from 1)		C81 C86 H98
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:3hct, PDBe:3hct, PDBj:3hct
PDBsum3hct
PubMed19465916
UniProtQ9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Gene Name=TRAF6)

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