Structure of PDB 3grb Chain A Binding Site BS03

Receptor Information

>3grb Chain A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPMHEHAEVVFTANDSGPRRYTIAA
MLSPYSYSTTAVVTNP

Ligand information

InChI=1S/Zn/q+2

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Zn

Name

ZINC ION

PDB chain

3grb Chain A Residue 134 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	3grb Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition.
Resolution	1.75 Å
Binding residue (original residue number in PDB)	H31 E72 D74
Binding residue (residue number reindexed from 1)	H22 E63 D65
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0070324	thyroid hormone binding

	Biological Process
GO:0006144	purine nucleobase metabolic process
GO:0007165	signal transduction

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0035578	azurophil granule lumen
GO:0070062	extracellular exosome

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Cellular Component

External links

PDB	RCSB:3grb, PDBe:3grb, PDBj:3grb
PDBsum	3grb
PubMed	20659897
UniProt	P02766\|TTHY_HUMAN Transthyretin (Gene Name=TTR)

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