Structure of PDB 3gme Chain A Binding Site BS03

Receptor Information
>3gme Chain A (length=482) Species: 331111 (Escherichia coli O139:H28 str. E24377A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLNPIVRKFQYGQHTVTLETGMMARQATAAVMVSMDDTAVFVTVVGQKKA
KPGQDFFPLTVNYQERTYAAGRIPGSFRPSEGETLIARLIDRPIRPLFPE
GFVNEVQVIATVVSVNPQVNPDIVAMIGASAALSLSGIPFNGPIGAARVG
YINDQYVLNPTQDELKESKLDLVVAGTEAAVLMVESEAELLSEDQMLGAV
VFGHEQQQVVIQNINELVKEAGKPRWDWQPEPVNEALNARVTDKQERYLH
AIEKNVVRSRVLAGEPRIDGREKDMIRGLDVRTGVLPRTHGSALFTRGET
QALVTATLGTDTFLFHYNFPPYSVGETGMVGSPKRREIGHGRLAKRGVLA
VMPDMDKFPYTVRVVSEITESNGSSSMASVCGASLALMDAGVPIKAAVAG
IAMGLVKEGDNYVVLSDILGDEDHLGDMDFKVAGSRDGISALQMDIKIEG
ITKEIMQVALNQAKGARLHILGVMEQAINAPR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3gme Chain A Residue 551 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3gme Crystal structure of Escherichia coli polynucleotide phosphorylase core bound to RNase E, RNA and manganese: implications for catalytic mechanism and RNA degradosome assembly.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		F41 V42 T43 I114 T116
Binding residue
(residue number reindexed from 1)		F41 V42 T43 I109 T111
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.8: polyribonucleotide nucleotidyltransferase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004654 polyribonucleotide nucleotidyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0006402 mRNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3gme, PDBe:3gme, PDBj:3gme
PDBsum3gme
PubMed19327365
UniProtA7ZS61|PNP_ECO24 Polyribonucleotide nucleotidyltransferase (Gene Name=pnp)

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