Structure of PDB 3brd Chain A Binding Site BS03

Receptor Information

>3brd Chain A (length=427) Species: 6239 (Caenorhabditis elegans)

VQSLTSDRMIDFLSNKEKYECVISIFHAKVAQKSYGNEKRFFCPPPCIYL
IGQGWKLKKDRVAQLYKTLQQATELVAYIGIGSDTSERQQLDFPNIYDYC
AAKTLYISDSDKRKYFDLNAQFFYGCGMEIGGFVSQRIKVISKPSKKKTD
CKYLCIASGTKVALFNRLRSQTVSTRYLHVEGNAFHASSTKWGAFTIHLF
DDQETDNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKVDKQQVILDAS
CSEEPVSQLHKCAFQMIDNELVYLCLSHDKIIQHQATAINEHRHQINDGA
AWTIISTDKAEYRFFEAMGQVANPISPCPVVGSLEVDGHGEASRVELHGR
DFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTHWMFTNRTTG
DVEVPISLVRDDGVVYSSGLTFSYKSL

Ligand information

>3brd Chain D (length=15) Species: 6239 (Caenorhabditis elegans)

RRMINASVWMPPMEN

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3brd RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex.
• Resolution: 2.21 Å
• Binding residue (original residue number in PDB): A414 F415 D431 D440 N441 F442 A443 V444 D446 G463 I464 A465 P467 I515 Q517 H518
• Binding residue (residue number reindexed from 1): A184 F185 D201 D206 N207 F208 A209 V210 D212 G229 I230 A231 P233 I281 Q283 H284

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:3brd, PDBe:3brd, PDBj:3brd
• PDBsum: 3brd
• PubMed: 18381292
• UniProt: V6CLJ5|LAG1_CAEEL Suppressor of hairless protein homolog (Gene Name=lag-1)