Structure of PDB 3boy Chain A Binding Site BS03

Receptor Information

>3boy Chain A (length=147) Species: 1423 (Bacillus subtilis)

TLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGSMDAHKVI
AAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVG
LRFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI

Ligand information

• Ligand ID: HIS
• InChI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/p+1/t5-/m0/s1
• InChIKey: HNDVDQJCIGZPNO-YFKPBYRVSA-O
• SMILES:
  OpenEye OEToolkits 1.5.0: c1c([nH+]c[nH]1)CC(C(=O)O)N
  CACTVS 3.341: N[CH](Cc1c[nH]c[nH+]1)C(O)=O
  CACTVS 3.341: N[C@@H](Cc1c[nH]c[nH+]1)C(O)=O
  ACDLabs 10.04: O=C(O)C(N)Cc1cnc[nH+]1
  OpenEye OEToolkits 1.5.0: c1c([nH+]c[nH]1)C[C@@H](C(=O)O)N
• Formula: C6 H10 N3 O2
• Name: HISTIDINE
• PDB chain: 3boy Chain A Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3boy Crystal Structure of Activated HutP: An RNA Binding Protein that Regulates Transcription of the hut Operon in Bacillus subtilis
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): R88 R98 G130 A131 H138
• Binding residue (residue number reindexed from 1): R87 R97 G129 A130 H137
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003729 mRNA binding

Biological Process

• GO:0006547 L-histidine metabolic process
• GO:0010628 positive regulation of gene expression

External links

• PDB: RCSB:3boy, PDBe:3boy, PDBj:3boy
• PDBsum: 3boy
• UniProt: P10943|HUTP_BACSU Hut operon positive regulatory protein (Gene Name=hutP)