Structure of PDB 3bo5 Chain A Binding Site BS03

Receptor Information

>3bo5 Chain A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TEQLDVACGQENLPVGAWPPGAAPAPFQYTPDHVVGPGADIDPTQITFPG
CICVKTPCLPGTCSCLRHGENYDDNSCLRDKYAEPVFECNVLCRCSDHCR
NRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQ
RRIHLQTKSDSNYIIAIREHVMETFVDPTYIGNIGRFLNHSCEPNLLMIP
VRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSASKERLDHGKLR
KPCYCGAKSCTAFLPFDSS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

3bo5 Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3bo5 The Crystal Structure of Methyltransferase Domain of Human Histone-lysine N-methyltransferase SETMAR in Complex With AdoHcy.
Resolution	1.59 Å
Binding residue (original residue number in PDB)	C61 C63 C68 C73
Binding residue (residue number reindexed from 1)	C51 C53 C58 C63
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	Y154 Y248
Catalytic site (residue number reindexed from 1)	Y139 Y228
Enzyme Commision number	2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase. 3.1.-.-

Gene Ontology

	Molecular Function
GO:0008270	zinc ion binding
GO:0042054	histone methyltransferase activity

	Cellular Component
GO:0005634	nucleus

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Molecular Function

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Cellular Component

External links

PDB	RCSB:3bo5, PDBe:3bo5, PDBj:3bo5
PDBsum	3bo5
PubMed
UniProt	Q53H47\|SETMR_HUMAN Histone-lysine N-methyltransferase SETMAR (Gene Name=SETMAR)

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