Structure of PDB 3a9y Chain A Binding Site BS03

Receptor Information
>3a9y Chain A (length=403) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTAR
ASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQQTLGTRPHFITC
TVEHDSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLV
TIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKR
RVDVEDLGVDFLTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERN
FRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIRDYLEERLEAEFGKR
IHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDH
EDRPSPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQLE
GPV
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain3a9y Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3a9y Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		G283 T284
Binding residue
(residue number reindexed from 1)		G254 T255
Annotation score1
Enzymatic activity
Enzyme Commision number 4.4.1.16: selenocysteine lyase.
Gene Ontology
Molecular Function
GO:0009000 selenocysteine lyase activity
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0016829 lyase activity
GO:0042803 protein homodimerization activity
GO:0070279 vitamin B6 binding
Biological Process
GO:0001887 selenium compound metabolic process
GO:0006629 lipid metabolic process
GO:0016261 selenocysteine catabolic process
GO:0032868 response to insulin
GO:1900408 negative regulation of cellular response to oxidative stress
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:1902494 catalytic complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3a9y, PDBe:3a9y, PDBj:3a9y
PDBsum3a9y
PubMed20164179
UniProtQ68FT9|SCLY_RAT Selenocysteine lyase (Gene Name=Scly)

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