Structure of PDB 3a6p Chain A Binding Site BS03

Receptor Information
>3a6p Chain A (length=1072) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMDQVNALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKCPICVPCG
LRLAEKTQVAIVRHFGLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANG
TLNILEEENHIKDALSRIVVEMIKREWPQHWPDMLIELDTLSKQGETQTE
LVMFILLRLAEDVVTFQTLPPQRRRDIQQTLTQNMERIFSFLLNTLQENV
NKYQQVKTDTSQESKAQANCRVGVAALNTLAGYIDWVSMSHITAENCKLL
EILCLLLNEQELQLGAAECLLIAVSRKGKLEDRKPLMVLFGDVAMHYILS
AAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGADSDVETPSNFGK
YLESFLAFTTHPSQFLRSSTQMTWGALFRHEILSRDPLLLAIIPKYLRAS
MTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQQGEVMRLAC
RLDPKTSFQMAGEWLKYQLSTFSLCSVFSPSFVQWEAMTLFLESVITQMF
RTLNREEIPVNDGIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYRPE
FLPQVFSKLFSSVTFETVEESKAPRTRAVRNVRRHACSSIIKMCRDYPQL
VLPNFDMLYNHVKQLLSNELLLTQMEKCALMEALVLISNQFKNYERQKVF
LEELMAPVASIWLSQDMHRVLSDVDAFIAYVGTDQKDPGLEDPCGLNRAR
MSFCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSGNPIFRNPCTEQIL
KLLDNLLALIRTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGLPQPL
LELNDSPVFKTVLERMQRFFSTLYENCFHILGKAGPSMQQDFYTVEDLAT
QLLSSAFVNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLF
TYLHMRLSQKWQVINQRESQEMLEEQLVRMLTREVMDLITVCCVSELTDL
GKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTL
LADAVTWLFTSVLKGLQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAV
MEQIPEIQKDSLDQFDCKLLNP
Ligand information
>3a6p Chain E (length=24) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcuuucagucggauguuugccgc
........................
Receptor-Ligand Complex Structure
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PDB3a6p A high-resolution structure of the pre-microRNA nuclear export machinery
Resolution2.92 Å
Binding residue
(original residue number in PDB)		K278 A441 E445 R448 R593 R602 T641 Q642 M643 G715 R718 K830 R835 R838 L1042 Q1045 R1046 H1086
Binding residue
(residue number reindexed from 1)		K277 A440 E444 R447 R575 R584 T623 Q624 M625 G695 R698 K810 R815 R818 L978 Q981 R982 H1022
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
GO:0070883 pre-miRNA binding
GO:1905172 RISC complex binding
Biological Process
GO:0006405 RNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0010586 miRNA metabolic process
GO:0015031 protein transport
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0035281 pre-miRNA export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0042565 RNA nuclear export complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3a6p, PDBe:3a6p, PDBj:3a6p
PDBsum3a6p
PubMed19965479
UniProtQ9HAV4|XPO5_HUMAN Exportin-5 (Gene Name=XPO5)

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