Structure of PDB 2ywr Chain A Binding Site BS03

Receptor Information

>2ywr Chain A (length=216) Species: 63363 (Aquifex aeolicus)

MLKIGVLVSGRGSNLQAIIDAIESGKVNASIELVISDNPKAYAIERCKKH
NVECKVIQRKEFPSKKEFEERMALELKKKGVELVVLAGFMRILSHNFLKY
FPNKVINIHPSLIPAFQGLHAQKQAVEFGVKFSGCTVHIVDESVDAGPVI
VQAVVPVLPEDDENTLADRILKWEHKILPQTVQWFAQDRIIIDGRKVIVK
DATYGTLPVNPALEIF

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 2ywr Chain A Residue 767

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2ywr Structures and reaction mechanisms of the two related enzymes, PurN and PurU.
• Resolution: 1.77 Å
• Binding residue (original residue number in PDB): I44 K48 C54
• Binding residue (residue number reindexed from 1): I44 K48 C54
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): N107 H109 T136 D145
• Catalytic site (residue number reindexed from 1): N107 H109 T136 D145
• Enzyme Commision number: 2.1.2.2: phosphoribosylglycinamide formyltransferase 1.

Gene Ontology

Molecular Function

• GO:0004644 phosphoribosylglycinamide formyltransferase activity
• GO:0016740 transferase activity

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006189 'de novo' IMP biosynthetic process
• GO:0009058 biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:2ywr, PDBe:2ywr, PDBj:2ywr
• PDBsum: 2ywr
• PubMed: 24108189
• UniProt: O67023