Structure of PDB 2ykg Chain A Binding Site BS03

Receptor Information
>2ykg Chain A (length=636) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLYSKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQ
GQKGKVVFFANQIPVYEQNKSVFSKYFERHGYRVTGISGATAENVPVEQI
VENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIM
FNYLDQKLGGSSGPLPQVIGLTASVGVGDAKTTDEALDYICKLCASLDAS
VIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAK
RICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVDEESRICKALFLYTS
HLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEK
LQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDAL
KNWIEGNPKLSFLKPGIDHNILIATSVADEGAQCNLVILYEYVVIKMRGS
KCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTH
EKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEDCHYTVLGD
AFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPV
IKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2ykg Chain A Residue 927 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2ykg Structural Insights Into RNA Recognition by Rig-I.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		C810 C813 C864 C869
Binding residue
(residue number reindexed from 1)		C524 C527 C578 C583
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2ykg, PDBe:2ykg, PDBj:2ykg
PDBsum2ykg
PubMed22000018
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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