Structure of PDB 2y9x Chain A Binding Site BS03

Receptor Information
>2y9x Chain A (length=391) Species: 5341 (Agaricus bisporus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDKKSLMPLVGIPGEIKNRLNILDFVKNDKFFTLYVRALQVLQARDQSDY
SSFFQLGGIHGLPYTEWAKAQPQLHLYKANYCTHGTVLFPTWHRAYESTW
EQTLWEAAGTVAQRFTTSDQAEWIQAAKDLRQPFWDWGYWPNDPDFIGLP
DQVIRDKQVEITDYNGTKIEVENPILHYKFHPIEPTFEGDFAQWQTTMRY
PDVQKQENIEGMIAGIKAAAPGFREWTFNMLTKNYTWELFSNHGAVVGAH
ANSLEMVHNTVHFLIGRDPTLDPLVPGHMGSVPHAAFDPIFWMHHCNVDR
LLALWQTMNYDVYVSEGMNREATMGLIPGQVLTEDSPLEPFYTKNQDPWQ
SDDLEDWETLGFSYPDFDPVKGKSKEEKSVYINDWVHKHYG
Ligand information
Ligand ID0TR
InChIInChI=1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9)
InChIKeyMDYOLVRUBBJPFM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.352OC1=CC=CC=CC1=O
OpenEye OEToolkits 1.6.1C1=CC=C(C(=O)C=C1)O
FormulaC7 H6 O2
Name2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE;
TROPOLONE
ChEMBLCHEMBL121188
DrugBank
ZINCZINC000000392003
PDB chain2y9x Chain A Residue 410 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2y9x Crystal Structure of Agaricus Bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		N260 H263 F264 V283
Binding residue
(residue number reindexed from 1)		N259 H262 F263 V282
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.18.1: tyrosinase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:2y9x, PDBe:2y9x, PDBj:2y9x
PDBsum2y9x
PubMed21598903
UniProtC7FF04|PPO3_AGABI Polyphenol oxidase 3 (Gene Name=PPO3)

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