Structure of PDB 2xzl Chain A Binding Site BS03

Receptor Information
>2xzl Chain A (length=756) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSCAYCGIDSAKCVIKCNSCKKWFCNTKNGTSSSHIVNHLVLSHHNVVSL
HPDSDLGDTVLECYNCGRKNVFLLGFVSVVLLCRIPCAQTKWDTDQWQPL
IEDRQLLSWVAEQPTEEEKLKARLITPSQISKLEAKWRSNKDATIPPLLL
RYQDAYEYQRSYGPLIKLEADYDKQLKESQEHISVSWSLALNNRHLASFT
KVAIGDEMILWYSGMQHPDWEGRGYIVRLPNDTFTLELKPSKTPPPTHLT
TGFTAEFIWKGTSYDRMQDALKKFAIDKKSISGYLYYKILGHQVVDISFD
VPLPKEFSIPNFAQLNSSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIV
YHLSKIHKDRILVCAPSNVAVDHLAAKLRDLGLKVVRLTAKSREDVESSV
SNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEIL
NKADVVCCTCVGAGDKRLDTKFRTVLIDESTQASEPECLIPIVKGAKQVI
LVGDHQQLGPVILERKAADAGLKQSLFERLISLGHVPIRLEVQYRMNPYL
SEFPSNMFYEGSLQNGVTIEQRTVPNSKFPWPIRGIPMMFWANYGREEIS
ANGTSFLNRIEAMNCERIITKLFRDGVKPEQIGVITPYEGQRAYILQYMQ
MNGSLDKDLYIKVEVASVDAFQGREKDYIILSCVRANEQQAIGFLRDPRR
LNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREKGCLVEGTLDNLQL
CTVQLV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2xzl Chain A Residue 1852 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2xzl Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C76 H98 H104
Binding residue
(residue number reindexed from 1)		C17 H39 H45
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xzl, PDBe:2xzl, PDBj:2xzl
PDBsum2xzl
PubMed21419344
UniProtP30771|RENT1_YEAST ATP-dependent helicase NAM7 (Gene Name=NAM7)

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