Structure of PDB 2x2e Chain A Binding Site BS03

Receptor Information
>2x2e Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRD
FLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAET
DRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQ
IRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVIT
KLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAE
RKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLL
SIEKEVEEYKNFRPDKHGTDSRVDEMLRMYHALKEALSIIG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2x2e Chain A Residue 1746 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2x2e G Domain Dimerization Controls Dynamin'S Assembly-Stimulated Gtpase Activity.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S45 T65
Binding residue
(residue number reindexed from 1)		S40 T60
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2x2e, PDBe:2x2e, PDBj:2x2e
PDBsum2x2e
PubMed20428113
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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