Structure of PDB 2wjf Chain A Binding Site BS03

Receptor Information

>2wjf Chain A (length=244) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GMIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRRKGMFE
TPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTL
NDSRYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKR
VRELIDMGCYTQVNSSHVLKPKLFGERYKFMKKRAQYFLEQDLVHVIASD
MHNLDGRPPHMAEAYDLVTQKYGEAKAQELFIDNPRKIVMDQLI

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

2wjf Chain A Residue 1246 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	2wjf Crystal Structures of Wzb of Escherichia Coli and Cpsb of Streptococcus Pneumoniae, Representatives of Two Families of Tyrosine Phosphatases that Regulate Capsule Assembly.
Resolution	2.22 Å
Binding residue (original residue number in PDB)	H5 H7 E80 D199
Binding residue (residue number reindexed from 1)	H6 H8 E81 D200
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

	Molecular Function
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0030145	manganese ion binding

	Biological Process
GO:0000271	polysaccharide biosynthetic process
GO:0045227	capsule polysaccharide biosynthetic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:2wjf, PDBe:2wjf, PDBj:2wjf
PDBsum	2wjf
PubMed	19616007
UniProt	Q9AHD4\|CPSB_STRPN Tyrosine-protein phosphatase CpsB (Gene Name=cpsB)

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