Structure of PDB 2v1u Chain A Binding Site BS03

Receptor Information
>2v1u Chain A (length=382) Species: 56636 (Aeropyrum pernix) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LESKIFRKRWVLLPDYVPDVLPHREAELRRLAEVLAPALRGEKPSNALLY
GLTGTGKTAVARLVLRRLEARASSLGVLVKPIYVNARHRETPYRVASAIA
EAVGVRVPFTGLSVGEVYERLVKRLSRLRGIYIIVLDEIDFLPKRPGGQD
LLYRITRINQELVSLVGITNSLGFVENLEPRVKSSLGEVELVFPPYTAPQ
LRDILETRAEEAFNPGVLDPDVVPLCAALAAREHGDARRALDLLRVAGEI
AERRREERVRREHVYSARAEIERDRVSEVVRTLPLHAKLVLLSIMMLEDG
GRPASTGEIYERYKELTSTLGLEHVTLRRVSGIISELDMLGIVKSRVVSR
GRYGKTREVSLDADRLAVENALSEDPFVARLL
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain2v1u Chain A Residue 1400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2v1u Structural Basis of DNA Replication Origin Recognition by an Orc Protein.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		L33 P34 T67 G68 K69 T70 A71 Y213 I221 R225 R255 L258
Binding residue
(residue number reindexed from 1)		L21 P22 T55 G56 K57 T58 A59 Y196 I204 R208 R238 L241
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006260 DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2v1u, PDBe:2v1u, PDBj:2v1u
PDBsum2v1u
PubMed17761880
UniProtQ9YEV6|CDC61_AERPE ORC1-type DNA replication protein 1 (Gene Name=orc1)

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