Structure of PDB 2ofi Chain A Binding Site BS03

Receptor Information
>2ofi Chain A (length=184) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQRCDWVSQDPLYIAYHDNEWGVPETDSRKLFEMICLEGQQAGLSWITVL
KKRENYRACFHQFDPIRIAAMQEEDVERLLQNTGIIRHRGKIQAIISNAR
AWLAMEQNGESFADFVWSFVDGQPQITQAASLDKIPTSTPASDALAKALK
KRGFKFVGTTICYSFMQACGLVNDHITGCFCHPG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2ofi Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ofi DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG).
Resolution1.85 Å
Binding residue
(original residue number in PDB)		C4 H17 H175 C179
Binding residue
(residue number reindexed from 1)		C4 H17 H175 C179
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.2.20: DNA-3-methyladenine glycosylase I.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008725 DNA-3-methyladenine glycosylase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2ofi, PDBe:2ofi, PDBj:2ofi
PDBsum2ofi
PubMed17410210
UniProtQ8Z2A5

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