Structure of PDB 2mip Chain A Binding Site BS03

Receptor Information
>2mip Chain A (length=99) Species: 11709 (Human immunodeficiency virus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGI
GGFINTKEYKNVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
Ligand information
Receptor-Ligand Complex Structure
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PDB2mip Crystal structure of human immunodeficiency virus (HIV) type 2 protease in complex with a reduced amide inhibitor and comparison with HIV-1 protease structures.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		D25 G27 A28 D29 G48 G49 P81 I82 I84
Binding residue
(residue number reindexed from 1)		D25 G27 A28 D29 G48 G49 P81 I82 I84
Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.47: HIV-2 retropepsin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2mip, PDBe:2mip, PDBj:2mip
PDBsum2mip
PubMed8378311
UniProtP04584|POL_HV2RO Gag-Pol polyprotein (Gene Name=gag-pol)

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