Structure of PDB 2lhi Chain A Binding Site BS03

Receptor Information
>2lhi Chain A (length=176) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSSNLTEEQIAEFKEAFALFDKDNNGSISSSELATVMRSLGLSPSEAEVN
DLMNEIDVDGNHQIEFSEFLALMSRQLKSNDSEQELLEAFKVFDKNGDGL
ISAAELKHVLTSIGEKLTDAEVDDMLREVSDGSGEINIQQFAALLSKGSS
TGTRRKALRNKILAIAKVSRMFSVLR
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2lhi Chain A Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2lhi Solution structures of yeast Saccharomyces cerevisiae calmodulin in calcium- and target peptide-bound states reveal similarities and differences to vertebrate calmodulin.
ResolutionN/A
Binding residue
(original residue number in PDB)		D93 N95 D97 L99 E104
Binding residue
(residue number reindexed from 1)		D94 N96 D98 L100 E105
Annotation score1
Enzymatic activity
Enzyme Commision number ?
3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030234 enzyme regulator activity
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
GO:0051019 mitogen-activated protein kinase binding
Biological Process
GO:0000742 karyogamy involved in conjugation with cellular fusion
GO:0006606 protein import into nucleus
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007010 cytoskeleton organization
GO:0007114 cell budding
GO:0010968 regulation of microtubule nucleation
GO:0016237 microautophagy
GO:0030050 vesicle transport along actin filament
GO:0042144 vacuole fusion, non-autophagic
GO:0051300 spindle pole body organization
GO:0071474 cellular hyperosmotic response
GO:1903525 regulation of membrane tubulation
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0000131 incipient cellular bud site
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0005823 central plaque of spindle pole body
GO:0005856 cytoskeleton
GO:0005933 cellular bud
GO:0005934 cellular bud tip
GO:0005935 cellular bud neck
GO:0030479 actin cortical patch
GO:0031475 myosin V complex
GO:0043332 mating projection tip
GO:0045160 myosin I complex
GO:0051286 cell tip

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2lhi, PDBe:2lhi, PDBj:2lhi
PDBsum2lhi
PubMed22280008
UniProtP06787|CALM_YEAST Calmodulin (Gene Name=CMD1);
P23287

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