Structure of PDB 2jam Chain A Binding Site BS03

Receptor Information

>2jam Chain A (length=279) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSSLENEIAVLK
KIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLV
IQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQN
GIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEET
ESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALS
HPWIDGNTALHRDIYPSVSLQIQKNFAKS

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

2jam Chain A Residue 1306 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	2jam Crystal Structure of Human Calmodulin-Dependent Protein Kinase I G
Resolution	1.7 Å
Binding residue (original residue number in PDB)	L284 H285
Binding residue (residue number reindexed from 1)	L260 H261
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	D144 K146 N149 D165 T183
Catalytic site (residue number reindexed from 1)	D120 K122 N125 D141 T159
Enzyme Commision number	2.7.11.17: calcium/calmodulin-dependent protein kinase.

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2jam, PDBe:2jam, PDBj:2jam
PDBsum	2jam
PubMed
UniProt	Q96NX5\|KCC1G_HUMAN Calcium/calmodulin-dependent protein kinase type 1G (Gene Name=CAMK1G)

[Back to BioLiP]