Structure of PDB 2ixv Chain A Binding Site BS03

Receptor Information
>2ixv Chain A (length=338) Species: 10747 (Streptococcus phage Cp1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKKNDLFVDVSSHNGYDITGILEQMGTTNTIIKISESTTYLNPCLSAQVE
QSNPIGFYHFARFGGDVAEAEREAQFFLDNVPMQVKYLVLDYQDDPSGDA
QANTNACLRFMQMIADAGYKPIYYSYKPFTHDNVDYQQILAQFPNSLWIA
GYGLNDGTANFEYFPSMDGIRWWQYSSNPFDKNIVLLDDEEDDKPKTAGT
WKQDSKGWWFRRNNGSFPYNKWEKIGGVWYYFDSKGYCLTSEWLKDNEKW
YYLKDNGAMATGWVLVGSEWYYMDDSGAMVTGWVKYKNNWYYMTNERGNM
VSNEFIKSGKGWYFMNTNGELADNPSFTKEPDGLITVA
Ligand information
Ligand IDDGN
InChIInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m1/s1
InChIKeyZDXPYRJPNDTMRX-GSVOUGTGSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)N)C(C(=O)O)N
ACDLabs 10.04O=C(N)CCC(N)C(=O)O
OpenEye OEToolkits 1.5.0C(CC(=O)N)[C@H](C(=O)O)N
CACTVS 3.341N[CH](CCC(N)=O)C(O)=O
CACTVS 3.341N[C@H](CCC(N)=O)C(O)=O
FormulaC5 H10 N2 O3
NameD-GLUTAMINE
ChEMBLCHEMBL1232207
DrugBankDB02174
ZINCZINC000001532609
PDB chain2ixv Chain A Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ixv Elucidation of the Molecular Recognition of Bacterial Cell Wall by Modular Pneumococcal Phage Endolysin Cpl-1.
Resolution1.96 Å
Binding residue
(original residue number in PDB)		G154 Y164
Binding residue
(residue number reindexed from 1)		G153 Y163
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D10 D92 Q94 D182
Catalytic site (residue number reindexed from 1) D9 D91 Q93 D181
Enzyme Commision number 3.2.1.17: lysozyme.
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0005515 protein binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2ixv, PDBe:2ixv, PDBj:2ixv
PDBsum2ixv
PubMed17581815
UniProtP15057|LYS_BPCP1 Lysozyme (Gene Name=CPL1)

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