Structure of PDB 2hp2 Chain A Binding Site BS03

Receptor Information
>2hp2 Chain A (length=427) Species: 269084 (Synechococcus elongatus PCC 6301) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FKTIKSDEIFAAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKDAYAWDVD
GNRYIDYVGTWGPAICGHAHPEVIEALKVAMEKGTSFGAPCALENVLAEM
VNDAVPSIEMVRFVNSGTEACMAVLRIMRAYTGRDKIIKFEGCYHGHADM
FLVKAGSGVATLGLPSSPGVPKKTTANTLTTPYNDLEAVKALFAENPGEI
AGVILEPIVGNSGFIVPDAGFLEGLREITLEHDALLVFDEVMTGFRIAYG
GVQEKFGVTPDLTTLGKIIGGGLPVGAYGGKREIMQLVAPAGPMYQAGTL
SGNPLAMTAGIKTLELLRQPGTYEYLDQITKRLSDGLLAIAQETGHAACG
GQVSGMFGFFFTEGPVHNYEDAKKSDLQKFSRFHRGMLEQGIYLAPSQFE
AGFTSLAHTEEDIDATLAAARTVMSAL
Ligand information
Ligand IDHOZ
InChIInChI=1S/C5H12N2O2/c6-3-4(7)1-2-5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1
InChIKeyPQGAAJQIFBEYSA-BYPYZUCNSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)O)[C@@H](CN)N
OpenEye OEToolkits 1.5.0C(CC(=O)O)C(CN)N
CACTVS 3.341NC[CH](N)CCC(O)=O
CACTVS 3.341NC[C@@H](N)CCC(O)=O
ACDLabs 10.04O=C(O)CCC(N)CN
FormulaC5 H12 N2 O2
Name(4S)-4,5-DIAMINOPENTANOIC ACID
ChEMBL
DrugBank
ZINCZINC000038792051
PDB chain2hp2 Chain B Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2hp2 Intersubunit signaling in glutamate-1-semialdehyde-aminomutase.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		G1304 T1305
Binding residue
(residue number reindexed from 1)		G298 T299
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) V1027 Y1150 D1245 M1248 K1273 A1407
Catalytic site (residue number reindexed from 1) V21 Y144 D239 M242 K267 A401
Enzyme Commision number 5.4.3.8: glutamate-1-semialdehyde 2,1-aminomutase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0016853 isomerase activity
GO:0030170 pyridoxal phosphate binding
GO:0042286 glutamate-1-semialdehyde 2,1-aminomutase activity
Biological Process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0015995 chlorophyll biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2hp2, PDBe:2hp2, PDBj:2hp2
PDBsum2hp2
PubMed16954186
UniProtP24630|GSA_SYNP6 Glutamate-1-semialdehyde 2,1-aminomutase (Gene Name=hemL)

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