Structure of PDB 2hc9 Chain A Binding Site BS03

Receptor Information
>2hc9 Chain A (length=489) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TQVLVRNGIQAVGDGLTSLIIVGKKSVLKNVTFEGKFKEVAQKFVTDGDS
WNSMISRIPASGRHPLHYELAHLITVPDASSRGNTPTNAHSIYKELKPIN
YPEDTKNVHFVLFAEYPDVLSHVAAIARTFCKFSMKTSGIRELNVNIDVV
CDKLTNEDAVFLTDLSESVRETARLIDTPANILTTDALVDEAVKVGNATG
SKITVIRGEELLKAGFGGIYHVGKAGPTPPAFVVLSHEVPGSTEHIALVG
KGVVYDTGGLQIKTKTGMPNMKRDMGGAAGMLEAYSALVKHGFSQTLHAC
LCIVENNVSPIANKPDDIIKMLSGKTVEINNTDAEGRLILADGVFYAKET
LKATTIFDMATLTGAQAWLSGRLHGAAMTNDEQLENEIIKAGKASGDLVA
PMLFAPDLFFGDLKSSIADMKNSNLGKMDGPPSAVAGLLIGAHIGFGEGL
RWLHLDIAAPAEVGDRGTGYGPALFSTLLGKYTSVPMLK
Ligand information
Ligand IDBCT
InChIInChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
InChIKeyBVKZGUZCCUSVTD-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)(O)[O-]
CACTVS 3.341OC([O-])=O
ACDLabs 10.04[O-]C(=O)O
FormulaC H O3
NameBICARBONATE ION
ChEMBL
DrugBank
ZINC
PDB chain2hc9 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2hc9 Crystal Structure and Function of Caenorhabditis Elegans Leucine Aminopeptidase
Resolution1.85 Å
Binding residue
(original residue number in PDB)		A335 E336 G337 R338 L363
Binding residue
(residue number reindexed from 1)		A334 E335 G336 R337 L362
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) K264 R338
Catalytic site (residue number reindexed from 1) K263 R337
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
GO:0040009 regulation of growth rate
GO:0046662 regulation of egg-laying behavior
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hc9, PDBe:2hc9, PDBj:2hc9
PDBsum2hc9
PubMed
UniProtP34629|AMPL_CAEEL Leucine aminopeptidase 1 (Gene Name=lap-1)

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