Structure of PDB 2f4o Chain A Binding Site BS03

Receptor Information

>2f4o Chain A (length=290) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GDSTILKVLQSNIQHVQLYENPVLQEKALTCIPVSELKRKAQEKLFRARK
LDKGTNVSDEDFLLLELLHWFKEEFFRWVNNIVCSKCGGETRSRDEALLP
NDDELKWGAKNVENHYCDACQLSNRFPRYNNPEKLLETRCGRCGEWANCF
TLCCRALGFEARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYE
IGWGKKLSYIIAFSKDEVVDVTWRYSCKHDEVMSRRTKVKEELLRETING
LNKQRQLSLSESRRKELLQRIIVELVEFISPKTPHHHHHH

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

2f4o Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2f4o Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways.
Resolution	2.26 Å
Binding residue (original residue number in PDB)	H454 H455 H457
Binding residue (residue number reindexed from 1)	H286 H287 H289
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.5.1.52: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase.

External links

PDB	RCSB:2f4o, PDBe:2f4o, PDBj:2f4o
PDBsum	2f4o
PubMed	16500903
UniProt	Q9JI78\|NGLY1_MOUSE Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (Gene Name=Ngly1)

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