Structure of PDB 2e3x Chain A Binding Site BS03

Receptor Information

>2e3x Chain A (length=416) Species: 343250 (Daboia siamensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QFNKIFIELVIIVDHSMAKKCNSTATNTKIYEIVNSANEIFNPLNIHVTL
IGVEFWCDRDLINVTSSADETLNSFGEWRASDLMTRKSHDNALLFTDMRF
DLNTLGITFLAGMCQAYRSVGIVQEQGNRNFKTAVIMAHELSHNLGMYHD
GKNCICNDSSCVMSPVLSDQPSKLFSNCSIHDYQRYLTRYKPKCIFNPPL
RKDIVSPPVCGNEIWEEGEECDCGSPANCQNPCCDAATCKLKPGAECGNG
LCCYQCKIKTAGTVCRRARDECDVPEHCTGQSAECPRDQLQQNGKPCQNN
RGYCYNGDCPIMRNQCISLFGSRANVAKDSCFQENLKGSYYGYCRKENGR
KIPCAPQDVKCGRLFCLNNSPRNKNPCNMHYSCMDQHKGMVDPGTKCEDG
KVCNNKRQCVDVNTAY

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

2e3x Chain A Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2e3x Crystal structure of RVV-X: an example of evolutionary gain of specificity by ADAM proteinases.
Resolution	2.91 Å
Binding residue (original residue number in PDB)	V215 N218 I220 E222 E225 D228
Binding residue (residue number reindexed from 1)	V209 N212 I214 E216 E219 D222
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.24.58: russellysin.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:2e3x, PDBe:2e3x, PDBj:2e3x
PDBsum	2e3x
PubMed	18060879
UniProt	Q7LZ61\|VM3CX_DABSI Coagulation factor X-activating enzyme heavy chain

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