Structure of PDB 2dpk Chain A Binding Site BS03

Receptor Information
>2dpk Chain A (length=124) Species: 9615 (Canis lupus familiaris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HGIPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTA
NAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVKVS
SESALACLGSPSTATVTIFDDDHA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2dpk Chain A Residue 3001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2dpk The crystal structure of the primary Ca2+ sensor of the na+/ca2+ exchanger reveals a novel Ca2+ binding motif.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E385 D447 I449 E451 D498 D500
Binding residue
(residue number reindexed from 1)		E19 D81 I83 E85 D120 D122
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0007154 cell communication
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:2dpk, PDBe:2dpk, PDBj:2dpk
PDBsum2dpk
PubMed16774926
UniProtP23685|NAC1_CANLF Sodium/calcium exchanger 1 (Gene Name=SLC8A1)

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