Structure of PDB 2dkc Chain A Binding Site BS03

Receptor Information
>2dkc Chain A (length=536) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSIEQTLSQYLPSHPKPQGVTFTYGTAGFRMKADKLDYVTFTVGIIASLR
SKYLQGKTVGVMITASHNPPEDNGVKVVDPLGSMLESSWEKYATDLANAS
PSPNSLVEVIKNLVSDLKIDLSIPANVVIARDSRESSPALSMATIDGFQS
VPNTKYQDFGLFTTPELHYVTRTLNDPDFGKPTEDGYYSKLAKSFQEIYT
ICESNNEKIDITIDAANGVGAPKIQELLEKYLHKEISFTVVNGDYKQPNL
LNFDCGADYVKTNQKLPKNVKPVNNKLYASFDGDADRLICYYQNNDNKFK
LLDGDKLSTLFALFLQQLFKQIDPTKISLNIGVVQTAYANGSSTKYVEDV
LKIPVRCTPTGVKHLHHEAENFDIGVYFEANGHGTVIFNPEAEKKIFDYK
PNNDNEAKAIKVLQNFSQLINQTVGDAISDLLAVLIVVHYLKLSPSDWDN
EYTDLPNKLVKVIVPDRSIFKTTNAERTLVEPKGMQDEIDKLVAQYPNGR
SFVRASGTEDAVRVYAEADTQNNVEELSKAVSELVK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2dkc Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2dkc Crystal Structures of N-Acetylglucosamine-phosphate Mutase, a Member of the {alpha}-D-Phosphohexomutase Superfamily, and Its Substrate and Product Complexes.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		S66 D290 D292 D294
Binding residue
(residue number reindexed from 1)		S66 D282 D284 D286
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) S66 H67 K76
Catalytic site (residue number reindexed from 1) S66 H67 K76
Enzyme Commision number 5.4.2.3: phosphoacetylglucosamine mutase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004610 phosphoacetylglucosamine mutase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006031 chitin biosynthetic process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0071555 cell wall organization

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2dkc, PDBe:2dkc, PDBj:2dkc
PDBsum2dkc
PubMed16651269
UniProtQ9P4V2|AGM1_CANAX Phosphoacetylglucosamine mutase (Gene Name=AGM1)

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