Structure of PDB 2cv1 Chain A Binding Site BS03

Receptor Information
>2cv1 Chain A (length=468) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVVTRIAPSPTGDPHVGTAYIALFNYAWARRNGGRFIVRIEDTDRARYVP
GAEERILAALKWLGLSYDEGPDVGGPHGPYRQSERLPLYQKYAEELLKRG
WAYRAFETPEELEQIRKEKGGYDGRARNIPPEEAEERARRGEPHVIRLKV
PRPGTTEVKDELRGVVVYDNQEIPDVVLLKSDGYPTYHLANVVDDHLMGV
TDVIRAEEWLVSTPIHVLLYRAFGWEAPRFYHMPLLRNPDKTKISKRKSH
TSLDWYKAEGFLPEALRNYLCLMGFSMPDGREIFTLEEFIQAFTWERVSL
GGPVFDLEKLRWMNGKYIREVLSLEEVAERVKPFLREAGLSWESEAYLRR
AVELMRPRFDTLKEFPEKARYLFTEDYPVSEKAQRKLEEGLPLLKELYPR
LRAQEEWTEAALEALLRGFAAEKGVKLGQVAQPLRAALTGSLETPGLFEI
LALLGKERALRRLERALA
Ligand information
Ligand IDGAU
InChIInChI=1S/C5H11NO3/c6-4(3-7)1-2-5(8)9/h4,7H,1-3,6H2,(H,8,9)/t4-/m0/s1
InChIKeyJPYGFLFUDLRNKX-BYPYZUCNSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)O)C(CO)N
ACDLabs 10.04O=C(O)CCC(N)CO
OpenEye OEToolkits 1.5.0C(CC(=O)O)[C@@H](CO)N
CACTVS 3.341N[CH](CO)CCC(O)=O
CACTVS 3.341N[C@H](CO)CCC(O)=O
FormulaC5 H11 N O3
Name(4S)-4-AMINO-5-HYDROXYPENTANOIC ACID;
L-GLUTAMOL
ChEMBL
DrugBank
ZINCZINC000033836585
PDB chain2cv1 Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2cv1 Glutamyl-tRNA synthetase from Thermus thermophilus in complex with tRNA(Glu), ATP, and an analog of L-glutamate: a quaternary complex
Resolution2.41 Å
Binding residue
(original residue number in PDB)		R5 A7 E41 Y187 R205 W209
Binding residue
(residue number reindexed from 1)		R5 A7 E41 Y187 R205 W209
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) K246
Catalytic site (residue number reindexed from 1) K246
Enzyme Commision number 6.1.1.17: glutamate--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004818 glutamate-tRNA ligase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006424 glutamyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2cv1, PDBe:2cv1, PDBj:2cv1
PDBsum2cv1
PubMed
UniProtP27000|SYE_THET8 Glutamate--tRNA ligase (Gene Name=gltX)

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