Structure of PDB 2ch9 Chain A Binding Site BS03

Receptor Information
>2ch9 Chain A (length=126) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFNNCTNDMFLFKESR
ITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTLKQTLSC
YSEVWVVPWLQHFEVPVLRCHHHHHH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2ch9 Chain A Residue 1156 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ch9 Structural Basis of Reduction-Dependent Activation of Human Cystatin F.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H146 H149
Binding residue
(residue number reindexed from 1)		H122 H125
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004866 endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0030414 peptidase inhibitor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006955 immune response
GO:0010466 negative regulation of peptidase activity
GO:0031643 positive regulation of myelination
GO:1903979 negative regulation of microglial cell activation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ch9, PDBe:2ch9, PDBj:2ch9
PDBsum2ch9
PubMed16601115
UniProtO76096|CYTF_HUMAN Cystatin-F (Gene Name=CST7)

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