Structure of PDB 2bcu Chain A Binding Site BS03

Receptor Information
>2bcu Chain A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEA
CSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTA
QMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTV
QKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLD
SLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEF
ACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGR
VLPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB2bcu Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase
Resolution2.2 Å
Binding residue
(original residue number in PDB)		W274 Q372 V462 S463 Q464 Q470 Q471 K472 R514 R517 K521 L527 S528 E529 H530 H541 K544 V545
Binding residue
(residue number reindexed from 1)		W25 Q123 V213 S214 Q215 Q221 Q222 K223 R265 R268 K272 L278 S279 E280 H281 H292 K295 V296
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D178 D180 D241
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2bcu, PDBe:2bcu, PDBj:2bcu
PDBsum2bcu
PubMed16439207
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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