Structure of PDB 2bcr Chain A Binding Site BS03

Receptor Information
>2bcr Chain A (length=325) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEAC
SIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQ
MWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQ
KAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDS
LRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFA
CALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRV
LPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2bcr Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase
Resolution1.75 Å
Binding residue
(original residue number in PDB)		W274 V462 S463 Q464 Q471 K472 R514 R517 K521 L527 S528 E529 H530 H541 K544 V545 P547
Binding residue
(residue number reindexed from 1)		W24 V212 S213 Q214 Q221 K222 R264 R267 K271 L277 S278 E279 H280 H291 K294 V295 P297
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D177 D179 D240
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2bcr, PDBe:2bcr, PDBj:2bcr
PDBsum2bcr
PubMed16439207
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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