Structure of PDB 2b1o Chain A Binding Site BS03

Receptor Information
>2b1o Chain A (length=212) Species: 44689 (Dictyostelium discoideum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVDANKVKFFFGKNCTGESFEYNKGETVRFNNGDKWNDKFMSCLVGSNVR
CNIWEHNEIDTPTPGKFQELAQGSTNNDLTSINGLSKFQVLPGAFQWAVD
VKIVNKVNSTAGSYEMTITPYQVDKVACKDGDDFVQLPIPKLTPPDSEIV
SHLTVRQTHTPYDYVVNGSVYFKYSPTTGQVTVIKKDETFPKNMTVTQDD
NTSFIFNLNSEK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2b1o Chain A Residue 215 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2b1o Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion
ResolutionN/A
Binding residue
(original residue number in PDB)		E59 D61 T179 Q181 N202
Binding residue
(residue number reindexed from 1)		E58 D60 T178 Q180 N201
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0042802 identical protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0010468 regulation of gene expression
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0030587 sorocarp development
GO:0031152 aggregation involved in sorocarp development
GO:0031288 sorocarp morphogenesis
GO:0050829 defense response to Gram-negative bacterium
GO:0051702 biological process involved in interaction with symbiont
GO:0098609 cell-cell adhesion
GO:1904643 response to curcumin
Cellular Component
GO:0000331 contractile vacuole
GO:0001726 ruffle
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005938 cell cortex
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030139 endocytic vesicle
GO:0030175 filopodium
GO:0031012 extracellular matrix
GO:0045335 phagocytic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2b1o, PDBe:2b1o, PDBj:2b1o
PDBsum2b1o
PubMed17057715
UniProtP54657|CAD1_DICDI Calcium-dependent cell adhesion molecule 1 (Gene Name=cadA)

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