Structure of PDB 2ask Chain A Binding Site BS03

Receptor Information
>2ask Chain A (length=101) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLL
GAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCL
G
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain2ask Chain A Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ask Artemin crystal structure reveals insights into heparan sulfate binding.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		H32 R33 S34 D93 V94
Binding residue
(residue number reindexed from 1)		H20 R21 S22 D81 V82
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008083 growth factor activity
GO:0030116 glial cell-derived neurotrophic factor receptor binding
GO:0030971 receptor tyrosine kinase binding

View graph for
Molecular Function
External links
PDB RCSB:2ask, PDBe:2ask, PDBj:2ask
PDBsum2ask
PubMed16734417
UniProtQ5T4W7|ARTN_HUMAN Artemin (Gene Name=ARTN)

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