Structure of PDB 2a62 Chain A Binding Site BS03

Receptor Information

>2a62 Chain A (length=319) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQI
NDITGDIHAIKRLDREEKAEYTLTAQAVDFETNKPLEPPSEFIIKVQDIN
DNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE
GQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTT
LTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQS
SYDIIGTALFEITSDAQAQDGVIRLRKPLDFETKKSYTLKVEAANIHIDP
RFSSRGPFKDTATVKIVVE

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

2a62 Chain A Residue 325 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2a62 Type II cadherin ectodomain structures: implications for classical cadherin specificity.
Resolution	4.5 Å
Binding residue (original residue number in PDB)	E11 E12 D64 E66 D101
Binding residue (residue number reindexed from 1)	E11 E12 D64 E66 D101
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:2a62, PDBe:2a62, PDBj:2a62
PDBsum	2a62
PubMed	16564015
UniProt	P97291\|CADH8_MOUSE Cadherin-8 (Gene Name=Cdh8)

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