Structure of PDB 1z26 Chain A Binding Site BS03

Receptor Information
>1z26 Chain A (length=716) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMKAIVVINLVKINKKIIPDKIYVYRLYSIYRLAYENVGIVIDPENLIIA
TTKELEYEGEFIPEGEISFSELRNDYQSKLVLRLLKENGIGEYELSKLLR
KFRKPKTFGDYKVIPSVEMSVIKHDEDFYLVIHIIHQIQSMKTLWELVNK
DPKELEEFLMTHKENLMLKDIASPLKTVYKPCFEEYTKKPKLDHNQEIVK
YWYNYHIERYWNTPEAKLEFYRKFGQVDLKQPAILAKFASKNYKIYLLPQ
LVVPTYNAEQLAKEILEYTKLMPEERKELLENILAEVDSDIIDKSLSEIE
VEKIAQELENKIRVRDDKGNSVPISQLLWTNYSRKYPVILPYEVPEKFRK
IREIPMFIILDSGLLADIQNFATNEFRELVKSMYYSLAKKYKEKVITEDL
NSDKGIIEVVEQVSSFMKGKELGLAFIAARNKLSSEKFEEIKRRLFNLNV
ISQVVNEDTLKNKRDKYDRNRLDLFVRHNLLFQVLSKLGVKYYVLDYRFN
YDYIIGIDVAPMKRSEGYIGGSAVMFDSQGYIRKIVPIKIGEQRGESVDM
NEFFKEMVDKFKEFNIKLDNKKILLLRDGRITNNEEEGLKYISEMFDIEV
VTMDVIKNHPVRAFANMKMYFNLGGAIYLIPHKLKQAKGTPIPIKLAKKR
IIKNGKVEKQSITRQDVLDIFILTRLNYGSIRLPAPVHYAHKFANAIRNE
WKIKEEFLAEGFLYFV
Ligand information
Ligand IDWO4
InChIInChI=1S/4O.W/q;;2*-1;
InChIKeyPBYZMCDFOULPGH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-][W](=O)(=O)[O-]
ACDLabs 10.04
CACTVS 3.341		[O-][W]([O-])(=O)=O
FormulaO4 W
NameTUNGSTATE(VI)ION
ChEMBL
DrugBank
ZINC
PDB chain1z26 Chain A Residue 773 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1z26 Purified Argonaute2 and an siRNA form recombinant human RISC.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		N8 I143 H144 I145 R296 R662 F664
Binding residue
(residue number reindexed from 1)		N9 I132 H133 I134 R276 R612 F614
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0044355 clearance of foreign intracellular DNA

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1z26, PDBe:1z26, PDBj:1z26
PDBsum1z26
PubMed15800637
UniProtQ8U3D2|AGO_PYRFU Protein argonaute (Gene Name=ago)

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