Structure of PDB 1yvp Chain A Binding Site BS03

Receptor Information
>1yvp Chain A (length=529) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDQTQPLNEKQVPNSEGCYVWQVSDMNRLRRFLCFGSEGGTYYIEEKKLG
QENAEALLRLIEDGKGCEVVQEIKTFSQEGRAAKQEPTLFALAVCSQCSD
IKTKQAAFRAVPEVCRIPTHLFTFIQFKKDLKEGMKCGMWGRALRKAVSD
WYNTKDALNLAMAVTKYKQRNGWSHKDLLRLSHIKPANEGLTMVAKYVSK
GWKEVQEAYKEKELSPETEKVLKYLEATERVKRTKDELEIIHLIDEYRLV
REHLLTIHLKSKEIWKSLLQDMPLTALLRNLGKMTADSVLAPASSEVSSV
CERLTNEKLLKKARIHPFHILVALETYKKGHGLRWIPDTSIVEALDNAFY
KSFKLVEPTGKRFLLAIDVSASMNQRVLGSILNASVVAAAMCMLVARTEK
DSHMVAFSDEMLPCPITVNMLLHEVVEKMSDITMGSTDCALPMLWAQKTN
TAADIFIVFTDCETNVEDVHPATALKQYREKMGIPAKLIVCAMTSNGFSI
ADPDDRGMLDICGFDSGALDVIRNFTLDL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1yvp Structural Insights into RNA Quality Control: The Ro Autoantigen Binds Misfolded RNAs via Its Central Cavity
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R120 I121 T123 K170 Y171 R174 R252 V254 R255 E256 P277 T279 A280 R283 L313 K316 R318
Binding residue
(residue number reindexed from 1)		R116 I117 T119 K166 Y167 R170 R248 V250 R251 E252 P273 T275 A276 R279 L309 K312 R314
Binding affinityPDBbind-CN: Kd=5.2nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0034336 misfolded RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0030030 cell projection organization
Cellular Component
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1yvp, PDBe:1yvp, PDBj:1yvp
PDBsum1yvp
PubMed15907467
UniProtP42700|RO60_XENLA RNA-binding protein RO60 (Gene Name=ro60)

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