Structure of PDB 1x9n Chain A Binding Site BS03

Receptor Information
>1x9n Chain A (length=632) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAEMLPPPPLTASGVFSKFRDIARLTGSAS
TAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSL
TPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPV
LLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKY
DGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILD
TEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGES
LVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSC
EGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRG
KRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPS
PRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGIS
LRFPRFIRVREDKQPEQATTSAQVACLYRKQS
Ligand information
Receptor-Ligand Complex Structure
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PDB1x9n Human DNA ligase I completely encircles and partially unwinds nicked DNA.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R305 G416 A418 T420 R451 G453 A455 Q457 S458 R557 Q636 T639 R641 K642 R643 K644 R768 K770 R771 C794 K795 G797 S850 S852 P853 Y855 S869 L870
Binding residue
(residue number reindexed from 1)		R44 G147 A149 T151 R182 G184 A186 Q188 S189 R288 Q367 T370 R372 K373 R374 K375 R499 K501 R502 C525 K526 G528 S581 S583 P584 Y586 S600 L601
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1x9n, PDBe:1x9n, PDBj:1x9n
PDBsum1x9n
PubMed15565146
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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